Nibib r21 trailblazer

This award is an opportunity for early-career investigators to explore highly innovative research projects of high interest to the NIBIB. The primary goal of this research is to develop a new technology to enable simultaneous, high-resolution, whole-brain mapping of metabolites and neurotransmitters in clinically feasible time.

Metabolites and neurotransmitters can serve as potential biomarkers for neurological diseases such as epilepsy. Out of more than 3 million people who suffer from epilepsy in the US, the most common syndrome in adults is temporal lobe epilepsy which can often become a type known as mesial temporal sclerosis MTS - the degeneration of hippocampus in the temporal lobe of the brain. While some epilepsy symptoms can be managed with medication, others require surgical intervention. Currently, clinicians use EEG recordings and MRI imaging methods to identify the correct lateralization of the affected hippocampus noninvasively, but these methods can be challenging in that they have an inherent delay for diagnosis and not as effective as we hope in many cases.

Lam and the team believe that quantifying biochemical changes across the brain through tracking metabolites and neurotransmitters will improve the localization of epileptogenic foci ahead of surgery. These biochemical changes can also help monitor the progression of the disease and assist with its management.

nibib r21 trailblazer

Specifically, the team plans to use magnetic resonance spectroscopic imaging MRSI to simultaneously map and quantify metabolites and neurotransmitters without exogenous contrast agents. There are several fundamental technical challenges that the team needs to overcome to improve the currently very poor spatial resolution experiments with small brain coverages. However, the success of this research will create a powerful molecular neuroimaging tool that can impact the diagnosis, treatment and monitoring of epilepsy and potentially other neurological and neurodegenerative diseases.

In this section.An awardee may not hold concurrent Trailblazer awards. See Section III. Additional Information on Eligibility.

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This Trailblazer Award is an opportunity for New and Early Stage Investigators to pursue research programs of high interest to the NIBIB that integrate engineering and the physical sciences with the life and behavioral sciences. This FOA invites applications from researchers who are at the early stage of their independent careers or those who have not had substantial prior NIH funding.

A Trailblazer project may be exploratory, developmental, proof of concept, or high risk-high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven.

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Importantly, applicants are expected to propose research approaches for which there are minimal or no preliminary data. Standard dates apply, by PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Standard dates apply.

nibib r21 trailblazer

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Part 1. Overview Information Part 2. Full Text of the Announcement. Section I. Eligibility Information Section IV. Application and Submission Information Section V. Other Information.

The rapid evolution and vitality of the biomedical sciences benefits from the contributions and creativity of investigators in the early stages of their careers, and a continuous infusion of new ideas, techniques, and perspectives from other fields.

Such individuals include women, those from underrepresented racial and ethnic groups, those with disabilities, and those from disadvantaged backgrounds. The application of principles and techniques from engineering and the quantitative sciences such as physics, mathematics, chemistry and computer sciences is providing innovative technologies and novel methods to accelerate the pace of biomedical research, producing new understanding of disease mechanisms and translating these new discoveries to improve human health.

The Trailblazer Award seeks to catalyze the development of transdisciplinary research approaches with the potential to open new areas of biomedical investigation.Gregory A. The proposed project aims to develop biomaterials with integrated immunomodulatory enzymes as a new treatment modality for inflammatory diseases.

States of chronic inflammation resulting from aberrant immune system recognition of self as non-self are a significant clinical and financial burden because they are often incurable, and are typically managed by administering costly biologic drugs that can render patients immunodeficient or immunocompromised. With this award, the proposed research program will develop locally administered biomaterials that can recapitulate natural mechanisms to locally resolve inflammation via enzymes that catalyze the conversion of immunostimulatory signals to immunosuppressive signals.

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The Trailblazer R21 Award is an opportunity for new and early stage investigators to pursue research programs of high interest to the NIBIB at the interface of the life sciences with engineering and the physical sciences.

A Trailblazer project may be exploratory, developmental, proof of concept, or high risk-high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven.

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Skip to content. Search for:.The award is an opportunity for New and Early Stage Investigators to pursue research programs of high interest to the NIBIB that integrate engineering and the physical sciences with the life and behavioral sciences. It is a high risk-high impact grant program aimed at funding projects with the potential of creating a breakthrough in their field of research.

Arino-Estrada will work together with Professor Saif Islam, Electrical and Computer Engineering Department Chair, to improve the image quality in positron emission tomography PET and allow for early diagnosis of diseases and more efficient treatments.

They plan to achieve this by using tapered-hole microstructures in photodetectors to curve light and achieve a very high detection efficiency in a thin silicon layer. This concept can also improve the timing resolution of photodetectors by over an order of magnitude.

If the behavior of the photodetector is as good as expected, their integration into commercial PET scanners would be straightforward and could rapidly generate a high impact in the field. An improvement of this magnitude would allow for detection of lesions of just a few millimeters with an extremely high signal-to-background contrast that would lead to early diagnoses of cancer or brain diseases, among many other applications.

Home News Dr.Reissue of PAR An awardee may not hold concurrent Trailblazer awards.

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See Section III. Additional Information on Eligibility. This Trailblazer Award is an opportunity for New and Early Stage Investigators to pursue research programs of high interest to the NIBIB that integrate engineering and the physical sciences with the life and behavioral sciences.

Hudalla Awarded NIBIB Trailblazer R21 Award

This FOA invites applications from researchers who are at the early stage of their independent careers or those who have not had substantial prior NIH funding. A Trailblazer project may be exploratory, developmental, proof of concept, or high risk-high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven.

Importantly, applicants are expected to propose research approaches for which there are minimal or no preliminary data. Standard dates apply, by PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these dates.

Bioengineering professor Fan Lam receives NIBIB Trailblazer Award

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. Standard dates apply. Original Expiration Date: September 8, Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV.

When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Part 1. Overview Information Part 2. Full Text of the Announcement. Section I. Eligibility Information Section IV. Application and Submission Information Section V. Other Information. The rapid evolution and vitality of the biomedical sciences benefits from the contributions and creativity of investigators in the early stages of their careers, and a continuous infusion of new ideas, techniques, and perspectives from other fields.

Such individuals include women, those from underrepresented racial and ethnic groups, those with disabilities, and those from disadvantaged backgrounds.

The application of principles and techniques from engineering and the quantitative sciences such as physics, mathematics, chemistry and computer sciences is providing innovative technologies and novel methods to accelerate the pace of biomedical research, producing new understanding of disease mechanisms and translating these new discoveries to improve human health. The Trailblazer Award seeks to catalyze the development of transdisciplinary research approaches with the potential to open new areas of biomedical investigation.

A Trailblazer project may be exploratory, developmental, proof of concept or have high risk-high impact goals. Importantly, the proposed research for this FOA may be technology design-directed and may or may not be hypothesis-driven. In the context of this FOA, innovation encompasses approaches to address well-defined, unmet biomedical research needs through the development of new methods, ideas, or technologies; early steps along the path toward delivery of a new capability or method; and the integration of existing components in a previously unproven format.

nibib r21 trailblazer

High-impact projects will have the potential to transform our understanding or practice by applying an innovative approach to an appropriate biomedical challenge to generate informative and impactful data or craft a solution to a significant problem. For projects supported by a Trailblazer Award, successful results should provide a solid foundation for further research under other funding mechanisms, such as the R Trailblazer approaches are expected to differ substantially from current thinking or practice, therefore, extensive preliminary data demonstrating feasibility is an indication that the project is beyond the scope of this FOA.

Applicants can provide appropriate justification for the proposed work through literature citations, data from other sources, or analytical and computational models.

NIBIB Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)

The proposed research could involve considerable risk that the work may not be successful and applicants should clearly explain the significance of the work to allow the reviewers to determine whether the potential impact justifies these risks. Not all research endeavors will be suitable for this FOA. Projects that propose incremental improvements in well-established areas of investigation are not appropriate for this FOA. Other Information for award authorities and regulations.

Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Optional: Accepting applications that either propose or do not propose clinical trial s.September 17, in BME News. Jennifer A. Nichols, Ph. Crayton Pruitt Family Department of Biomedical Engineering, was recently awarded the National Institutes of Health NIH Trailblazer R21 Award for a project designed to use machine learning methods to understand the biomechanical mechanisms underlying force production in the hand. The award recognizes early stage or early career investigators pursuing research programs that explore the intersection of the life sciences with engineering and the physical sciences.

The interdisciplinary project is a collaborative effort between Nichols and Joel B. Harley, Ph. Restoring hand function remains an elusive goal for many clinical conditions, including stroke, osteoarthritis, amputation, and traumatic injury. As a critical step toward informing personalized treatments for the hand, the team will study how subject-specific differences influence hand function. Completion of this proposal will rely on the collection of three datasets that are designed to provide varying levels of biomechanical detail and require varying levels of effort to collect.

These datasets include 1 a simulation dataset containingsimulations fully describing all musculoskeletal parameters involved in hand force production, 2 a dense, biomechanical dataset that describes the kinematics, kinetics, and muscle activity required for hand force production in 30 adults, and 3 a sparse, clinically-inspired dataset that describes demographics, anthropometrics, and clinical metrics of hand function in adults.

The team will utilize machine learning methods to examine how subject-specific differences influence hand function and create subject-specific computer models from easy to obtain clinical data. Completion of this project will critically advance the ability to efficiently create subject-specific models of the hand and understand the biomechanical mechanism underlying hand force production.NIBIB seeks to improve health by promoting fundamental discoveries, design and development, and translation and assessment of technological capabilities in biomedical imaging and bioengineering, enabled by relevant areas of information science, physics, chemistry, mathematics, materials science, and computer sciences.

Applications that are outside the mission and program areas of the NIBIB will be returned without review. NIBIB supports hypothesis- design- technology- or problem-driven research relating to its mission.

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Program areas of interest to the NIBIB include all aspects of biomedical imaging and bioengineering relevant to improving health. A Trailblazer project may be exploratory, developmental, proof of concept, or high risk-high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven.

Importantly, applicants are expected to propose research approaches for which there are minimal or no preliminary data. These studies are expected to lead to breakthroughs in development of innovative techniques, agents, methodologies, models, or their applications. These studies may involve considerable risk that should be balanced by the potential high impact on human-health and related research. Applicants are expected to propose novel biomedical research approaches for which there is no preliminary data to demonstrate the feasibility of the proposed project.

A project may be exploratory, developmental, proof of concept, or high risk-high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven. We encourage your inquiries concerning NIBIB R21 grants and welcome the opportunity to answer questions from potential applicants. Randy King. Program Director.


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